The Chinese researchers’ observation regarding cancer cells themselves needs to be replicated and refined. I haven’t found any other observations of Clever-1 expression in solid tumor cancer cells being studied/discovered. Are there any?
When a cancer tumor is studied, it contains macrophages and Clever-1s on the endothelium of the tumor’s blood vessels and lymphatic vessels, which indeed seem to have some significance if they are regulated up or down. Tadayo refers in his dissertation “Role of Clever-1 in Leukocyte Trafficking and Inflammation”
to the work of Professor Marko Salmi (fun fact: Salmi is Faron’s 6th largest owner right now and Sirpa’s successor at inFllames) from 2004: “Upon inflammation, Clever-1 is upregulated on the blood endothelium of inflamed tissues, such as tissues undergoing wound healing, skin psoriasis and endothelium of melanoma metastasis. (Salmi et al., 2004)”