https://www.medrxiv.org/content/10.64898/2026.03.16.26348550v1
In CAR-T treatment, STAB1/Clever-1-positive macrophages also seem to be associated with a poor response. In the linked paper, cfRNA served as a biomarker for the immune environment in the study.
Conversely, we also discovered STAB1 cfRNA transcripts were elevated in non-responders. STAB1 encodes stabilin-1, a scavenger receptor expressed on immunosuppressive tumor-associated macrophages associated with T cell exclusion and poor prognosis. Together, these findings indicate that cfRNA captures both structural features of organized antitumor immunity and signatures of myeloid mediated immune suppression.