Article related to the previously featured Cancer Discovery piece:
The reason for immunotherapy failure is often found in macrophages (SPP1+) that maintain inflammation (IL-6, CRP) and simultaneously suppress T-cells, causing the treatment to fail.
Clever-1 is not mentioned there because it describes a phenomenon rather than a single target, but in practice, this is exactly the mechanism for which Bex is the clinical solution.
A simple blood test for CRP and IL-6 status, providing a biomarker for Bex.
