En tiedä mikä on oikea raportointitapa, mutta en vieläkään laita lappuja laitaan.![]()
EDIT:
Sijoittaja-alokas: Käännöksessä oli paha/pahoja käännösvirheitä, niin koetin tähän lisätä tuon tekstin alkuperäisellä kiellä eli englanniksi ja siten ettei ohjelma käännä sitä väkisin taas suomeksi ![]()
Beksmarilimabi** supports bone marrow recovery**
In treatment-naïve HR-MDS, 57% of patients who were transfusion-dependent (TD) at baseline successfully achieved transfusion independence (TI). Across the entire HR-MDS BEXMAB trial population, 23% of dependent patients converted to independence. Maintenance of TI was robust, with 65% of patients who entered the study transfusion-independent remaining so throughout treatment. Analysis of the bone marrow samples confirmed that the treatment increases erythrocyte, platelet, and leukocyte progenitors, providing biological validation for the clinical improvements in blood counts.
Dr. Petri Bono, Chief Medical Officer of Faron, added, “The new data on transfusion independence is clinically very meaningful. For MDS patients, freedom from regular transfusions is a major determinant of quality of life. By demonstrating that we can convert over half of frontline transfusion dependent patients to independence, while simultaneously driving deep molecular remissions in high-risk genetic subgroups, we are confirming that bexmarilimab acts on cancer cells and actively rehabilitates the bone marrow environment, which is a key differentiator compared to classical toxic drugs aiming to just kill cancer cells.”
The combination continues to demonstrate an excellent safety profile. There were no Grade 5 bexmarilimab-related adverse events across the HR-MDS cohort. The encouraging safety profile and clear efficacy signals support bexmarilimab’s advancement into a randomized Phase 3 registrational trial to address the urgent unmet need in patients with HR-MDS.