https://www.medrxiv.org/content/10.64898/2026.03.16.26348550v1
Myös B-solulymfooman CAR-T hoidossa STAB1/Clever-1-positiiviset makrofagit näyttävät liittyvän huonoon vasteeseen. Linkin paperissa cfRNA toimi tutkimuksen biomarkkerina immuuniympäristölle.
Conversely, we also discovered STAB1 cfRNA transcripts were elevated in non-responders. STAB1 encodes stabilin-1, a scavenger receptor expressed on immunosuppressive tumor-associated macrophages associated with T cell exclusion and poor prognosis. Together, these findings indicate that cfRNA captures both structural features of organized antitumor immunity and signatures of myeloid mediated immune suppression.